Fireworx Routing Question Options

[mcrein]

just purchased a TC Fireworx. would like to know if any have suggestions on the best way to connect it to my exisitng system. i usually play guitar/synth into a MOTU MK2 into a G4 1.25 running DP4.1. i have a mackie software controller but no mixer. i mix virtually.
right now i have the fireworx connected to my MK 2 by s/pdif in and out. i am playing my guitar through a line 6 pod into the fireworx analog ins. is there a better way to connect this up? the firworx has analog in/out, s/pdif/ and the usual digital connections.
also do i have to sync the Fireworx to my MK 2 through word clock?
any help would be much appreciated..
M