favorite virtual studio software? Options

Hi there
This is my first post to this list. You all seem like nice folks. Looking forward to speaking with you.

I'm wondering what people's feelings are on their favorite digital studio/sequencer software to use.

I need something very simple and easy to use that lets me use DSP plugins.

I love reason, but I need to be able to use DSP plugins, record audio, sequence midi, etc.

Cubase seems pretty good to me, and it's the software I'm most familiar with. I just want to make sure I'm not missing something.

Logic has been recommended by loads of people, but it seems too complicated to me.

Is there another one of these programs that just really simple and easy to use to bring together the other software (plugins, reason, soft synths) that I've gotten used to using? Will I be missing something by just going with what I'm familiar with and sticking with Cubase?